The COVID-19 pandemic further isolates marginalized people from general contact with others and, in particular, community resources and agencies, including spiritual and/or religious resources. Given this exacerbated isolation, known here as “COVID-19 isolation,” it is important for social workers to examine how we contribute to and/or assist in finding solutions to people’s compounded distress. In this chapter, we deconstruct how general counseling has taken up the Euro-western medicalized model of “mental illnesses.” Informed by insights from various social justice frameworks, including Mad studies, we examine and challenge problematic mainstream assumptions about dominant “mental illness” narratives. Mad studies present the less stigmatizing term “mental distress” as a more useful understanding and way of working with marginalized people. Furthermore, we advocate that “mental distress” and holistic healing are paradigms in harmony with social justice-centered interventions. Using empowering ideas related to “COVID-19 isolation,” we specifically reflect on examples concerning spiritual or religious resources that marginalized people experiencing mental distress may access. Working with spiritual or religious people going through mental distress can be complex for therapists. When spirituality or religion is added to the mix, some might presume the complications to be outside of their social work practice skill set. Acknowledging these complexities, we present practical strategies for working with spiritual and religious people experiencing mental distress. These considerations can contribute to increasing the general effectiveness of work done in a pandemic world with people in mental distress who access spiritual or religious resources.