The reconfiguration of supply chains is increasingly necessary due to constant changes in companies. Rather than individual supply chains, networks today emerge as the sum of supply chains, sharing similarities among them. This study aims to solve the redesign problem, embedded in the REDNURS methodology, whose solution sequence implements a two-phase modeling approach, one dynamic and one structural. The applied methodology is divided into two stages: first, a dynamic phase and then a static one. Based on a set of architectures, a mathematical programming model is developed to select a multi-business synergistic configuration as a solution for the static phase. The model is applied to the pharmaceutical distribution of medicines, considering three different types of clients. The results state a multi-channel chain configuration, in addition to an initial synergistic structure, that can reach optimized flows.