Prader Willi Syndrome (PWS) is a neuropsychiatric condition that occurs due to lack of expression of paternally active genes on the chromosome locus 15q11-q13. Persons with PWS experience symptoms of hyperphagia, obesity, intellectual developmental disorder, disruptive behaviors, and frequent skin picking. These symptoms prove challenging to manage and often require support of medical and mental and behavioral health teams. This chapter reviews the journey of a person with PWS who experienced many of the symptoms associated with this syndrome. It then explores what is known about the neuroanatomy and pathophysiology of this syndrome.