Robert’s story is a complicated combination of sepsis, medically refractory epilepsy, unusual gastroenterological reactivity, mood difficulties, and altered cognitive processing. Robert’s challenge has been not only with seizures and medical complications but also with mood difficulties severe enough to require inpatient psychiatric hospitalizations, and cognitive dysfunction including compromised language processing and memory. Bilateral hippocampal sclerosis may be at the root, but other presumed alterations in neural connectivity are likely involved. Robert’s progress towards recovery has been noteworthy because his hemispheric dominance for language seems to have shifted. He was presumably left hemisphere dominant for language given his right-handedness, but in the course of his illness, he apparently shifted to being right hemisphere-dominant for language tasks. A few years after the shift, Robert received a responsive neurostimulation device implant, which improved functionality, even while the seizure control continued to be challenging.