Constipation is one of the common symptoms encountered by pharmacists in their day-to-day practice. It involves symptoms of reduced defecation frequency (fewer than three defecations per week or more than 4 days with no bowel movement), unsatisfactory evacuation, and/or straining. Pharmacists play an important role in the assessment and management of patients with constipation. They can identify patients who need medical attention and those who are appropriate for self-care. Proper assessment requires taking a history regarding the characteristics of patients’ constipation and the presence of any associated symptoms. This is in addition to identifying red flags that prompt referral to healthcare practitioners. A knowledge of the patient’s medical and medication history allows proper selection and/or assessment of the appropriate pharmacological agents. In addition, it helps in identifying the possible precipitating factors for secondary constipation, which could be attributed to drugs or diseases.