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Pediatric cancers present unique biological challenges and remain a leading cause of disease-related death in children. While treatment advances have improved outcomes, progress is limited for many high-risk and relapsed tumors. Organoid technology—three-dimensional cultures derived from patient or stem cells—offers a powerful new platform to model pediatric tumors more accurately. This chapter explores the convergence of pediatric oncology and organoid technology, highlighting current applications, emerging models, and the potential to revolutionize both translational research and clinical care for children with cancer.

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Investigating Pediatric Diseases with Organoid Systems: When Pediatric Oncology Meets Organoid Technology

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  • 发表日期：

    2026年

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  • Fulden Aycan

摘要

Pediatric cancers present unique biological challenges and remain a leading cause of disease-related death in children. While treatment advances have improved outcomes, progress is limited for many high-risk and relapsed tumors. Organoid technology—three-dimensional cultures derived from patient or stem cells—offers a powerful new platform to model pediatric tumors more accurately. This chapter explores the convergence of pediatric oncology and organoid technology, highlighting current applications, emerging models, and the potential to revolutionize both translational research and clinical care for children with cancer.