Musculoskeletal metastasis can affect patients in various physical, mental, and social aspects of life. In this specific patient population, physical therapy (PT) has been shown to improve mobility and quality of life due to a variety of strategies that can be safely implemented in this specific patient population. PT strategies involve a multidisciplinary team approach in order to best comprehend a patient’s clinical scenario and bring forth a tailored program. Following a comprehensive initial assessment, PT strategies may include strength training, balance training, endurance training, and, as a result, functional mobility training. Weight bearing or range of motion restrictions for the specific impaired limb(s) should be considered in appendicular metastasis; while avoiding excessive spinal flexion, extension, and rotation as well as high impact such as hopping must be considered with axial metastasis. PT can help with a patient’s pain, but modalities that increase local blood flow such as electrical stimulation, thermotherapy, massage, and ultrasound should be avoided to reduce risk to the metastatic sites. Standardized outcome measures can be used to track patients’ functional progress over time.