This chapter presents quantitative findings comparing psychological constructs and mental health outcomes between international student samples from South Africa and Germany. Data analyses involved descriptive statistics, t-tests, correlation analyses, path analyses, moderation, and mediation analyses. Key findings indicated significant cross-national differences. South African students reported higher levels of acculturative stress, including perceived discrimination, homesickness, fear, stress due to culture shock, perceived hate, and social dysfunction, compared to their German counterparts. Conversely, psychological resources such as resilience, optimism, self-efficacy, and hope consistently served as protective factors against mental health difficulties, particularly within the German sample.