Openings in reinforced concrete (RC) flat plate floors are often required to facilitate utility ducts for electrical conduits, plumbing, HVAC systems, and other essential services. Typically, these openings are positioned near columns to optimize space utilization. However, such openings expose the slab-column connections, which are already under high shear and moment stresses, to significant strength reduction due to the reduction in the concrete area resisting shear and the interruption of flexural reinforcement at the opening locations. This strength reduction is more critical in edge connections where the anchorage of reinforcement becomes a challenge. Headed-end glass fiber-reinforced-polymer (GFRP) bars offer a solution to the anchorage problem; however, their low modulus of elasticity will further reduce the shear capacity of such connections. In this study, the impact of these openings on flat plate behaviour was investigated through the construction and testing of three full-scale slab-column edge connections reinforced with GFRP head-end bars until failure. Each specimen had the same geometry and reinforcement, differing only in the presence and location of the openings. The control specimen had no openings, the second connection had an opening at the front column face, and the third contains an opening at the side face of the column. The square openings had the same size as the column with a 300 mm side length. The performance of these connections was evaluated based on their load-carrying capacity, mode of failure, deflection, and strains observed in both concrete and reinforcement. The results indicate that openings located at the side face of the column exerted a smaller reduction in connection capacity compared to those at the column face.