Due to the aesthetic development in the architectural view of buildings, several columns have been invented, such as slanted columns. Strengthening, retrofitting, and repairing existing buildings has become a current issue, recently, due to the increase in residential and commercial capacity demand, in addition to, maintenance of poor-quality constructed buildings. This study investigates the effectiveness of Carbon Fiber Reinforced Polymer (CFRP) strengthening for slanted reinforced concrete (RC) columns through finite element analysis. Several parameters were considered that influence structural performance, including slanting angle (15°–60°), concrete compressive strength (30–90 MPa), CFRP thickness (1–6 layers), stirrup spacing (25–30 mm), bonding material properties, and plastic hinge behavior. Results demonstrate that CFRP wrapping significantly enhances load-bearing capacity and ductility, with optimal performance observed at moderate slant angles (≤45°). Increasing concrete strength from 30 MPa to 90 MPa improved capacity by 100–250%, while six CFRP layers provided up to 50% greater strength compared to a single layer. Tighter stirrup spacing (25 mm) further enhanced confinement, boosting capacity by up to 63% for 45° slanted columns. The study also compared CFRP with Glass Fiber Reinforced Polymer (GFRP), revealing that while CFRP offers higher ultimate strength, GFRP exhibits better deformation compatibility due to its lower elastic modulus. Additionally, bonding materials (e.g., elastomers) outperformed stiffer adhesives in stress redistribution. The findings provide practical guidelines for optimizing CFRP strengthening in slanted columns, emphasizing the importance of integrated design strategies that balance material efficiency, structural safety, and cost-effectiveness for seismic and eccentric loading conditions.