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In modern civilization, skin ageing has become one of the most prominent dermatological issues. In human existence, it becomes a complicated and inexorable process. The extracellular matrix is comprised of proteoglycans, including elastin, collagen, metalloproteinase (MMP) and fibronectin. Collagen and elastin are the most prevalent compounds present in the ECM matrix, serving the role of adherence factor, connective tissues, cellular conditions for growth and morphogenesis. The change of morphology, cell migration and tissue desorption has become significant in the remodulation of tissue during the degeneration of proteins, including cell growth, embryonic development and disease activity. Elastin and collagenase belong to the protease family and they control elastin and collagen breakdown along with some other ECM protein breakdown whilst enduring skin ageing. Photoaging due to UV radiation and solar exposure is another important aspect of skin ageing. It induces reactive oxygen species (ROS) formation that contributes to the reduction of skin elasticity. Therefore, demand for anti-collagenase and anti-elastase compounds has risen higher in order to prevent naïve skin ageing.

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Anti-collagenase and Anti-elastase Activities of Personal Care Products Made from Fungal Extracts

  • 章节

  • 发表日期：

    2026年

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  • Bandita Dutta,
  • Sedevino Ltu,
  • Dibyajit Lahiri,
  • Moupriya Nag,
  • Debasmita Bhattacharya,
  • Tanmay Sarkar,
  • Md Osim Aquatar,
  • Rina Rani Ray

摘要

In modern civilization, skin ageing has become one of the most prominent dermatological issues. In human existence, it becomes a complicated and inexorable process. The extracellular matrix is comprised of proteoglycans, including elastin, collagen, metalloproteinase (MMP) and fibronectin. Collagen and elastin are the most prevalent compounds present in the ECM matrix, serving the role of adherence factor, connective tissues, cellular conditions for growth and morphogenesis. The change of morphology, cell migration and tissue desorption has become significant in the remodulation of tissue during the degeneration of proteins, including cell growth, embryonic development and disease activity. Elastin and collagenase belong to the protease family and they control elastin and collagen breakdown along with some other ECM protein breakdown whilst enduring skin ageing. Photoaging due to UV radiation and solar exposure is another important aspect of skin ageing. It induces reactive oxygen species (ROS) formation that contributes to the reduction of skin elasticity. Therefore, demand for anti-collagenase and anti-elastase compounds has risen higher in order to prevent naïve skin ageing.