This chapter explores the concept of Culture-As-Interaction (CAI), offering a dynamic alternative to traditional views of culture as a static system of symbols or practices. Drawing on interdisciplinary perspectives from anthropology, psychology, and philosophy, CAI emphasizes culture as a living, adaptive process embedded in everyday social interactions. It addresses key questions such as: How do cultural norms shape, and get shaped by, embodied human interactions? How do practices of care, emotion, and identity co-evolve with cultural contexts? Through theoretical frameworks and practical examples—including addiction, emotional regulation, and personhood—this chapter examines how meaning emerges relationally rather than in isolation. The discussion introduces foundational thinkers such as Hacking, Morin, Rorty, Runciman, and critically engages with concepts like looping effects, cultural evolution, and narrative personhood. The chapter also considers clinical and public health contexts, linking CAI to applied domains such as harm reduction and other forms of care. By the end of the chapter, the core principles of Culture-As-Interaction (CAI) and its expression through Culture-As-Practice (CAP) will be clearly articulated, along with their implications for human development, well-being, and their relevance to contemporary social and psychological concerns.