According to the World Health Organization’s (WHO) recent definition of health, which emphasizes an individual’s capacity to adapt to their environment and maintain autonomy, this paper aims to explore the role of the built environment as a significant determinant of human health and well-being, particularly within the framework of the life course approach to the challenges of global population ageing. The discussion focuses on strategies aimed at promoting health by fostering stronger connections between the healthcare sector and the environmental design of adaptable and responsive living spaces, emphasizing the importance of interdisciplinarity and interprofessional collaboration in achieving this objective. The chapter adopts a methodological framework that combines a comprehensive review of existing literature with an analysis of relevant case studies. This approach facilitates the development of strategic models that integrate multiple disciplines, aiming to bridge the gap between the built environment and health. Key barriers and opportunities are explored for successfully integrating the design of the built environment into the promotion of human health, encompassing healthcare models, policies, and practices. This study presents a highly relevant discussion on the interplay between the built environment, public health, and well-being, particularly in light of contemporary global challenges such as demographic shifts and digitalization. The study emphasizes the need for innovative strategies to promote health by integrating environmental design into healthcare practices. By promoting interdisciplinarity and interprofessional collaboration, the research offers innovative insights into improving public health outcomes through integrated environmental and healthcare strategies. Although it is widely recognized that the built environment significantly influences health and well-being, affecting both daily functioning and longevity, health and the built environment are often treated as distinct domains in both practice and policy. Professionals in healthcare and in the built environment seldom collaborate in interdisciplinary teams, nor do they evaluate how local built environments impact public health. This lack of integration hinders the development of effective and sustainable solutions for communities.