Integrating Geographic Information Systems (GIS) and remote sensing in land-use management has revolutionized how policymakers, researchers, and educators analyze spatial dynamics and urban expansion. This study explores the application of GIS-based spatial analysis and remote sensing technologies in monitoring land-use and land-cover changes in the France–Monaco borderlands between 2000 and 2018. Utilizing the CORINE Land Cover (CLC) dataset, the study identifies key patterns of urbanization, land resource allocation, and environmental transformations. Findings reveal significant urban expansion, primarily replacing forests and agricultural land, while large-scale coastal developments have altered wetlands and water bodies. These changes emphasize the urgent need for data-driven decision-making and digital literacy in sustainable land management. Given the growing role of information technology in education, this research highlights how GIS and remote sensing tools can be integrated into academic curricula and professional training programs to equip future urban planning and policymaking process with essential digital skills. The study proposes a pedagogical framework for incorporating GIS-based learning into sustainability education, fostering interdisciplinary knowledge that bridges regional studies, environmental science, and innovative governance. Additionally, it underscores the role of cross-border cooperation (CBC) and digital learning platforms in promoting sustainable regional planning and transnational environmental policies. Therefore, by merging GIS education with sustainability studies, this research aligns with the broader objectives of the International Conference on Information Technology & Education, advocating for the advancement of geospatial literacy as a critical component of future-oriented education.