The design studio is the primary learning environment in architecture school, encouraging creativity, problem-solving, and technical abilities. However, the rigorous nature of studio culture, which includes long working hours, an intense workload, and high expectations, can have a severe impact on students’ mental health. This study investigates the impact of the design studio atmosphere on the mental health of architecture students at several Nigerian universities. Data was collected across 14 universities using structured questionnaires from 331 architecture students. The effects of key environmental and academic stressors, such as studio layout, workplace ergonomics, peer relationships, and project deadlines, on stress, anxiety, depression, and overall psychological health were assessed. The findings show that among architecture students, there is a substantial correlation between age and various aspects of academic stress, particularly workload and physical tiredness. For educators and academic advisors looking to promote student well-being in programs with high demand, these findings offer crucial insights. Overall, while students’ academic performance remains reasonably solid, the statistics show moderate to high levels of stress across a variety of psychological aspects. These findings highlight the necessity of offering mental health care and time management services to help students better manage academic stress.