Global health ethics has emerged as a broad ethical framework for the analysis of contemporary health challenges. It is not simply the expansion of the bioethics discourse but also the acknowledgment of health as a global concern and the globalization of ethical issues in healthcare. It articulates that new issues have emerged that usually do not figure on the agenda of bioethics, such as environmental degradation, climate change, pandemics, hunger, inequality, and poverty. Since processes of globalization and the new type of bioethical issues are linked, global health ethics requires a rethinking and enlargement of the normative framework, so that its moral concerns and approaches are no longer primarily focused on the perspective of the most developed countries. The development of global health ethics requires a delicate balance between applying and implementing a universal ethical framework (as for example, presented in the UNESCO Universal Declaration on Bioethics and Human Rights) and the need to recognize cultural and moral diversity as well as different local moral traditions. It furthermore requires a rethinking of the ethical framework for addressing global issues, as argued by Pope Francis in Laudato Si’, going beyond individual concerns and taking into account social and environmental concerns.