Prostate cancer (PCa) is a malignancy unique to males. Bone metastasis represents the most common adverse outcome in PCa, involving homing of malignant cells from primary tumor into the bone followed by its (tumor cell) final settlement and colonization to disrupt the normal osteoblast-osteoclast remodeling cycle. Signaling pathways like TGFβ, NFκB, Wnt/β-catenin, BMP, and PI3K/Akt have been found to play important role in PCa bone metastasis. Researches have elucidated the impact of microRNAs (miRNAs) in different signaling pathways associated with pathological conditions like cancer. miRNAs involve in silencing of target mRNAs by binding to their 3′ UTRs. Based on the target mRNAs (tumor suppressive/oncogenic), miRNAs may be oncogenic or tumor-suppressive, respectively, thus establishing their role in tumorigenesis as well as associated adverse outcomes. In this chapter, we discuss on various events of bone metastasis, the associated signaling pathways, and, the impact of miRNAs on regulation of said pathways to assess their (miRNAs) influence on the disease outcome for scientific and clinical interest.