This theoretical framework introduces the principle of dynamic and creative persistence (DCP) as a foundational paradigm for life. Drawing analogies to Newton’s laws of motion, three homeodynamic laws are also outlined: the conservation law related to homeostasis, the flow control law related to homeorhesis, and the codependency law related to homeopoiesis. Together, these laws support the autopoietic and teleonomic behavior of life, governing its persistence across molecular, cellular, organismal, and biospheric scales. Life is framed as a dynamic interplay of bioenergy, bioinformation, and biostructure, maintained through five interdependent processes: autopoiesis, homeodynamic control, creative emergence, codependency, and integrative unity. Cancer, within this framework, is reinterpreted as a pathological form of DCP: a self-organizing, metabolically reprogrammed biosystem that hijacks host regulatory mechanisms for survival. It disrupts homeodynamic balance, reverses biological causality, and reconfigures organismal unity. Cancer, viewed through this systemic lens, is not simply a mutation-driven local pathology but an ecological perturbation, an oncosphere, that reconfigures the internal biosphere of the host. The internal body climate, composed of biochemical, biophysical, and bioelectrical parameters modulated across scales, emerges as both the substrate and modulator of malignancy. The internal climate modulates cancer emergence and progression, while cancer, in turn, distorts systemic regulation, fueling a feedback loop of escalating instability. Mechanisms such as retrotransposition, centrosome amplification, and meiotic gene reactivation reflect cancer’s adaptive creativity, echoing evolutionary dynamics. By emphasizing systemic dysregulation, organismal codependence, and internal body climate-mediated feedback, this paradigm advocates for a shift from cellular eradication to climate reconstitution as a therapeutic strategy. Ultimately, understanding cancer as a product of systemic dysregulation—both a mirror and a driver of altered internal climate—provides a novel framework for biomarker development, early detection, and internal body climate-targeted therapeutic strategies. Cancer thus becomes not an error of individual cells but a disorder of dynamic equilibrium at the level of the whole organism.