This chapter explores cyclic causality as a universal principle fundamental to the persistence, adaptability, and evolution of living systems. Unlike classical causality, which is linear and reductionist, cyclic causality involves recursive, emergent feedback loops spanning molecular to planetary scales. It provides the structural basis for biological time, enabling rhythmicity, coherence, and self-organization. Through this lens, life is framed not as a static essence but as a dynamic, autopoietic, and autotelic process governed by multi-scale, interdependent interactions. Ultimately, cyclic causality is posited as the epistemological “glue” that links quantum systems, biological life, and cosmic processes, offering a new lens through which to understand life’s creative persistence. Central to this framework is the concept of dynamic and creative persistence (DCP)—the sustained union of bioenergy, bioinformation, and biostructure (the biocore), continually regulated through internal mechanisms and environmental interplay. Drawing from Gánti’s chemoton model and enriched by Kauffman, Pross, Wong, and others, I propose that life persists not merely by Darwinian evolution but through homeodynamic processes: homeostasis (stability), homeorhesis (developmental direction), and homeopoiesis (controlled novelty). This triadic model explains life across molecular, cellular, organismal, and planetary scales. Evolution is reinterpreted as a specific form of homeopoiesis, enabling species-level persistence through selective diversification rather than pure optimization. This reconceptualization reframes life not as a collection of forms but as a persistent, evolving process, a self-sustaining flow of energy, information, and structure that reinvents itself across space and time. Ultimately, life is a processual dance that neither evolution nor structure alone can define. It is the creative persistence of reciprocal matter-energy transformation itself. Cancer, too, is a homeodynamic process, driven by recursive feedback and niche formation, rather than solely Darwinian mechanisms. Cancer exemplifies a pathological form of DCP—a self-sustaining biosystem that reverts to more primitive, plastic states while maintaining a reorganized biocore. Cancer cells oscillate between unicellular and multicellular programs, between activity and dormancy, exploiting metabolic, epigenetic, and structural plasticity for survival.