Smart Construction Sites (SCS) represent a revolutionary advancement in the construction sector, integrating automated and intelligent systems to optimize the organization and progression of site activities and enhance resilience against disruptions. This study introduces a Discrete Event Simulation (DES) model in FlexSim to analyze the impact of material flow disruptions on key project performance indicators, notably project completion time. A case study demonstrates the simulation of an autonomous construction site system in which disruptions are generated. These disruptions propagate through various site activities, delaying construction processes and extending project timelines. Based on the simulation results, adaptive response strategies are proposed to mitigate the adverse effects of disruptions. These strategies include increasing system capacity such as the cadence of construction operations, ensuring a more resilient and efficient workflow under varying conditions.