Diabetic foot ulcers (DFUs) and wound healing are two of diabetes most common side effects. Despite tremendous advancements in the medical field, diabetic foot ulcers and wound healing are still challenging to treat. There are problems with the way DFUs and wounds are currently treated in diabetic conditions, including a lack of bioactivity and a reduced ability to facilitate wound healing. Recently, nanotherapeutics combined with metal biomaterials have demonstrated encouraging outcomes because they offer sufficient drug release to the site of action and promote quicker healing by demonstrating antioxidant and antibacterial properties. Furthermore, metal nano-biomaterials have a superior and more cost-effective adsorption capacity when it comes to wound healing and DFU treatment. As a result, we have discussed metal nano-biomaterials and nanotherapeutics for DFUs and wound healing. In conclusion, the pathophysiology of DFUs and reports on metal-based nano-biomaterials in wound healing have been discussed, along with their modes of action. A succinct review of the improved distribution method, clinical use, effectiveness, and potential future paths has also been given. Consequently, it emerged that nano-biomaterials for wound healing and DFU treatment were very effective in delivering drugs with antibacterial, biocompatible, wound-healing, and antioxidant properties, and can therefore be applied to new biomedical applications.