This chapter examines the essential role of families in fostering development, inclusion, and resilience in children with developmental disabilities and health conditions. Drawing from Family Systems and Ecological Systems theories, it emphasizes family-centered practice and advocates for collaborative, strengths-based partnerships between families and professionals. The chapter highlights evidence-based interventions, including caregiver-implemented strategies and coaching, that empower families to support child learning in daily routines. Components such as collaboration, feedback, problem solving, and routine-based learning are illustrated through early intervention models. The authors underscore improved child engagement, communication, functional skills, and caregiver competence as key outcomes of family capacity-building. The chapter also discusses advocacy, cultural responsiveness, and resource access, stressing the importance of practitioners honoring family priorities. By centering families in intervention planning, the chapter argues practitioners can strengthen child and family outcomes, and calls for continuous evaluation and adoption of family-centered, evidence-based practices.