Arterial Spin Labeling (ASL) MRI is a non-invasive, perfusion quantitative imaging MRI technique which uses endogenous contrast agent as a natural inflowing blood water this technique widely used to assess cerebral blood flow (CBF) in health conditions such as, stroke and neurological disorders. Its intrinsically low spatial resolution and signal-to-noise ratio (SNR) limit its clinical adaptability. For addressing these constraints, this paper reports a preprocessing and super resolution framework. Prior to CBF computation, image quality was improved using statistical noise removal and ASL volume super-resolution was then assessed using three 3D convolutional neural networks: these being SRCNN (Super resolution convolutional neural networks), EDSR3D (Enhanced Deep super resolution), and FSRCNN (Fast super resolution convolutional neural networks). Quantitative evaluation with computational metrics identified that FSRCNN performed better, providing a good anatomical accuracy in terms of PSNR which improved by 20.8% and SSIM which also improved by 8%. According to the findings, FSRCNN-based enhancement considerably raises the diagnostic quality of ASL-MRI, enabling more precise and trustworthy perfusion imaging in both clinical and research settings.