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This chapter reviewed intensity-modulated radiotherapy (IMRT) development history from the early 1990s to the 2020s, highlighting how a new technique such as IMRT evolved during this period. The concept of IMRT originated from the design of missing tissue compensators. Advancements in computer technology, computed tomography images, computer-controlled multiple-leaf collimators, and computer treatment planning optimization enable clinical implementation of IMRT from this early phase of sequential tomotherapy to volumetric-modulated arc therapy. The success of IMRT heralds imaging-guided treatment delivery, thus improving treatment precision and accuracy. The synergy of IMRT and IGRT leads to stereotactic body radiotherapy with a short treatment course and potent treatment regimens.

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History of Intensity-Modulated Radiotherapy: From Sequential Tomotherapy to Volumetric-Modulated Arc Therapy 2015–2023

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  • 发表日期：

    2025年

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  • Ping Xia,
  • Christopher Busch

摘要

This chapter reviewed intensity-modulated radiotherapy (IMRT) development history from the early 1990s to the 2020s, highlighting how a new technique such as IMRT evolved during this period. The concept of IMRT originated from the design of missing tissue compensators. Advancements in computer technology, computed tomography images, computer-controlled multiple-leaf collimators, and computer treatment planning optimization enable clinical implementation of IMRT from this early phase of sequential tomotherapy to volumetric-modulated arc therapy. The success of IMRT heralds imaging-guided treatment delivery, thus improving treatment precision and accuracy. The synergy of IMRT and IGRT leads to stereotactic body radiotherapy with a short treatment course and potent treatment regimens.