This chapter discusses a chitosan-based system for three-dimensional (3D)/four-dimensional (4D) (bio)printing for drug delivery and tissue-engineered scaffolds. These methodologies have advanced biomedical research into the digital manufacturing age by facilitating high-throughput and reproducibility, offering single-step assembly of a complex system that can be applied to heterogeneous components, and producing complex cellularized scaffolds. Several efforts have boosted control over scaffold construction, mechanical characteristics, and dynamic responsiveness to external stimuli by integrating chitosan into 3D and 4D printing platforms. These biofabrication techniques facilitate the development of intricate, cellular structures with exceptional precision and reproducibility, meeting the requirements of personalized treatment. Furthermore, the capacity to integrate therapeutic molecules directly into printable biomaterials enables localized, sustained drug delivery, thereby mitigating systemic toxicity and enhancing treatment efficacy. This chapter emphasizes the revolutionary influence of chitosan-based printable systems in advancing tissue engineering and drug delivery within the realm of digital, high-throughput biomedical manufacturing.