Orofacial pain (OFP) encompasses diverse conditions requiring a multidisciplinary approach to achieve effective diagnosis and management. This chapter highlights the integration of various healthcare professionals—including dental specialists, physicians, physical therapists, and behavioral health providers—in delivering patient-centered care. Emphasis is placed on comprehensive evaluation, accurate diagnosis, and the coordinated application of pharmacological, interventional, physical, and psychological therapies. Future directions include advancements in telemedicine, research on pain mechanisms, and interprofessional education to optimize outcomes and enhance quality of life for individuals with OFP.