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In this work, we present a highly sensitive method for the detection of biomolecules by Surface-Enhanced Raman Spectroscopy (SERS), exploiting the unique plasmonic properties of a silver (Ag) dendritic layer. This three-dimensional (3D) material is produced as a waste by-product during the metal-assisted chemical etching (MACE) process used to synthesize silicon nanowires. The fractal structure of the dendritic Ag layer is able to efficiently trap the light inside the micro- and nanocavities, forming numerous and very intense hot-spot regions that amplify Raman signals over a wide range of excitation wavelengths (from UV to IR spectral region). Furthermore, the sponge-like behavior of the Ag platform allows for the encapsulation and confinement of extremely small liquid volumes of the sample. This allows proteins to maintain their natural hydration shell, enabling the analysis of biomolecules in an environment that mimics the physiological conditions. This represents a significant advantage both in basic research and for biomedical and biochemical studies.

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Synthesis of Silver Dendrites as a Powerful SERS Platform for Hydrated Proteins Detection

  • 会议论文

  • 发表日期：

    2025年

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  • Dario Morganti,
  • Antonio Alessio Leonardi,
  • Maria Josè Lo Faro,
  • Sabrina Conoci,
  • Alessia Irrera,
  • Barbara Fazio

摘要

In this work, we present a highly sensitive method for the detection of biomolecules by Surface-Enhanced Raman Spectroscopy (SERS), exploiting the unique plasmonic properties of a silver (Ag) dendritic layer. This three-dimensional (3D) material is produced as a waste by-product during the metal-assisted chemical etching (MACE) process used to synthesize silicon nanowires. The fractal structure of the dendritic Ag layer is able to efficiently trap the light inside the micro- and nanocavities, forming numerous and very intense hot-spot regions that amplify Raman signals over a wide range of excitation wavelengths (from UV to IR spectral region). Furthermore, the sponge-like behavior of the Ag platform allows for the encapsulation and confinement of extremely small liquid volumes of the sample. This allows proteins to maintain their natural hydration shell, enabling the analysis of biomolecules in an environment that mimics the physiological conditions. This represents a significant advantage both in basic research and for biomedical and biochemical studies.