Blockchain technology is promising to transform healthcare by addressing challenges like data breaches, lack of interoperability, and trust issues. However, its adoption remains limited due to technical, organizational, and human barriers. While existing research has focused on technical and organizational aspects, the human factors influencing user adaptation—such as privacy concerns, high costs, lack of technical skills, and resistance to change—are often overlooked. This study bridges this gap by exploring how healthcare professionals, IT staff, and patients adapt to the blockchain using the Technology Acceptance Model (TAM) and Task-Technology Fit (TTF) frameworks. Through a mix of surveys and interviews, the study finds that privacy and motivation encourage adoption, while high costs hinder it. The alignment between blockchain’s features and healthcare tasks also plays a key role in shaping user intentions. These findings offer practical insights for policymakers, healthcare organizations, and technology developers to improve blockchain adoption strategies, emphasizing the importance of a user-centered approach for successful integration in healthcare.