The integration of technology into higher education has become increasingly prevalent, necessitating a re-evaluation of traditional teaching methodologies. This chapter addresses the shift towards blended learning and the crucial role of effectively designed virtual courses in this evolving landscape. It highlights the growing importance of online learning platforms and the need for universities to adapt to meet the changing expectations and learning habits of students. The rigidity observed at both institutional and teaching levels underscores the urgency for embracing new pedagogical approaches and providing educators with adequate training and resources. This chapter reflects on the design and implementation of blended learning strategies, drawing upon the practical experience of the authors at the University of Almería. Specifically, it examines a course where a meticulous approach to virtual classroom design has resulted in the highest evaluations from the university’s auditing service. The chapter details the key principles and best practices employed in creating these successful hybrid learning environments. It emphasizes the significance of a well-structured virtual classroom that facilitates student self-learning through accessible materials, interactive tools, and clear guidance. Furthermore, this work discusses the strengths and weaknesses of online instruction, underscoring its potential to enhance pedagogical effectiveness, improve access and flexibility, and offer cost efficiencies. However, it also acknowledges the challenges associated with providing course flexibility, promoting interaction, fostering student self-control, and ensuring technological competence among both instructors and students. The University of Almería’s comprehensive evaluation system for virtual courses, which assesses aspects such as course administration, content, activities, and student involvement, provides a framework for ensuring the quality of online teaching. By presenting a case study of a highly-rated hybrid course, “Mathematics of Financial Operations,” this chapter offers valuable insights into the practical application of these principles, showcasing the organization, resources, and tools utilized to create an engaging and effective blended learning experience. The findings contribute to the growing body of knowledge on successful online and hybrid course design in higher education.