This chapter provides a comprehensive examination of the innovative use of genetically modified microbes for metal bioaccumulation and detoxification in environmental remediation efforts. By leveraging genetic engineering techniques, microbes are tailored to enhance their ability to accumulate and detoxify heavy metals effectively. The chapter delves into the latest research findings and advancements in this burgeoning field, elucidating the intricate mechanisms and genetic modifications that empower microbes in these critical functions. Furthermore, the chapter explores the practical applications, persistent challenges, and potential future directions in employing genetically modified microbes for metal remediation, offering valuable insights for both researchers and practitioners in the field. With a focus on the synergy of biotechnology and environmental stewardship, this chapter underscores the promising role of genetically modified microbes in addressing metal pollution and fostering sustainable environmental management practices.