DT rely on a tight integration of physical assets, sensing devices, computation resources, and communication networks to maintain accurate, real-time representations of dynamic environments. The design of DT over wireless networks faces unique challenges due to the heterogeneous, high-volume, and time-sensitive nature of the data involved. Ensuring high-fidelity modeling, seamless bidirectional interaction, and reliable communication demands careful consideration of both hardware and software foundations, as well as advanced network protocols that support deterministic, low-latency, and synchronized operations. In this section, we systematically examine the key requirements and technical challenges that must be addressed to realize robust and scalable DT over wireless infrastructures.