The Spanish National Plan for Aerial Orthophotography (PNOA) has implemented the PNOA-LiDAR project, aimed at capturing three-dimensional information of the Spanish territory using airborne LiDAR (Light Detection and Ranging) sensors. Through this optical remote sensing technique, the second LiDAR flight coverage has achieved a resolution of up to 4 points per square metre and a root mean square error (RMSE) in altimetric measurement of less than 20 cm. This level of precision could enable the analysis of elevations and differential settlements in buildings associated with foundation failures or changes in ground conditions, provided that they exceed the LiDAR margin of error. This communication presents a case study of a house that, after its construction, experienced differential settlements greater than 20 cm, measured by topographic levelling on site, which were compared with measurements obtained from the LiDAR point cloud. The results obtained from the point cloud of the second PNOA-LiDAR coverage show acceptable deviations compared to the on-site measurements, providing valid information on the trend, direction, sense, and approximate magnitude of the differential movement. These findings confirm the potential of PNOA-LiDAR for the study of damage in buildings and civil engineering works associated with ground movements, as well as its application in this type of study on an urban scale.