Oil palm is an important cash crop for the oil palm-producing countries and the basal stem rot disease (BSR) of oil palm caused by Ganoderma boninense is a major limiting factor. This chapter elaborates on suppressive soils for oil palm and the challenges in adopting the suppressive soil approach for the management of BSR disease. There are only a few naturally occurring suppressive soils and they are either ‘general’ suppressive soil or ‘specific’ suppressive soil. The ‘specific’ disease suppression is highly effective. However, except for the exception of one soil, the Blenheim soil, there is no other documentation of the microbiome of soils with potential BSR suppression. The Blenheim soil was found in an oil palm plantation which has high calcareous shell deposits, has relatively high pH (pH 7–8) and a BSR incidence of less than 2% in 2028 while a non-suppressive soil had 30% BSR incidence. The suppressive Blenheim soil was observed to have a higher diversity of prokaryotes with higher abundance of bacterial taxa such as Alphaproteobacteria, Cyanobacteria, Firmicutes and genera Pseudomonas and Bacillus. Like in the case of other crop diseases, manipulation of soil pH and the introduction of beneficial microbes (biocontrol agents) have been observed to promote soil suppression. Various groups of beneficial microbes such as plant growth-promoting rhizobacteria (PGPR), arbuscular mycorrhizal fungi and mycoparasitic Trichoderma have been observed to produce soils with disease suppression of BSR up to 50–80%. However, the adoption of suppressive soils for BSR management has several challenges including the current research gap in understanding suppressive soils. Yet, it is believed that the suppressive soil technology has the potential to offer a positive outcome for farmers and consumers.