This chapter provides a comprehensive guide to navigating the opportunities and challenges of healthcare advertising on social media. It examines platform-specific audiences, content strategies, and engagement techniques tailored to Facebook, Instagram, TikTok, LinkedIn, YouTube, and Twitter/X. The chapter outlines compliance requirements under HIPAA, Federal Trade Commission rules, and truth-in-advertising standards, emphasizing the need to avoid misleading claims. Practical strategies are provided for understanding audience demographics, creating relevant and accurate content, and protecting patient privacy. The text also addresses best practices for engagement, managing negative feedback, and using analytics to measure performance against healthcare benchmarks. By integrating regulatory compliance, tailored messaging, and data-driven adjustments, healthcare providers can build credibility, increase patient acquisition, and foster trust through social media.