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There is no cure for chronic rejection of transplanted organs. Macrophages are heavily involved in chronic rejection. Macrophages’ movement into the graft depends on the actin cytoskeleton and its regulators the GTPase RhoA and its effector ROCK kinase. In this chapter, we describe how the interference with macrophage RhoA/ROCK pathway disrupts macrophage actin cytoskeleton, impairing their functions and migration to the allograft, and preventing the development of chronic rejection, and how such interference can be applied to clinical therapies.

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Macrophage Actin Cytoskeleton in Chronic Rejection

  • 章节

  • 发表日期：

    2026年

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  • Malgorzata Kloc,
  • Marta Halasa,
  • Souhail A. Thabet,
  • Jarek Wosik,
  • Ahmed Uosef,
  • Arijita Subuddhi,
  • Rafik Mark Ghobrial

摘要

There is no cure for chronic rejection of transplanted organs. Macrophages are heavily involved in chronic rejection. Macrophages’ movement into the graft depends on the actin cytoskeleton and its regulators the GTPase RhoA and its effector ROCK kinase. In this chapter, we describe how the interference with macrophage RhoA/ROCK pathway disrupts macrophage actin cytoskeleton, impairing their functions and migration to the allograft, and preventing the development of chronic rejection, and how such interference can be applied to clinical therapies.