The Framework Convention on Tobacco Control (FCTC) has been a transformative global health treaty, significantly advancing tobacco control policies worldwide. This chapter evaluates the implementation of FCTC demand reduction measures, including taxation, smoke-free laws, health warnings, and advertising bans, drawing on previous research. Findings reveal that FCTC ratification has accelerated the adoption of smoke-free laws and graphic health warnings, particularly in low- and middle-income countries, though voluntary agreements and weak state capacity have hindered progress. Advertising bans have been instrumental in reducing youth exposure to tobacco marketing, but enforcement gaps remain significant. While high- and upper-middle-income countries have made substantial progress, low-income and fragile states face persistent challenges due to limited implementation and monitoring resources and tobacco industry interference. The chapter underscores the need for stronger global collaboration, enhanced enforcement mechanisms, and expanded policies to address emerging products like e-cigarettes to sustain the FCTC’s impact on global public health.