Nipah virus (NiV) continues to be one of the most concerning emerging zoonotic pathogens due to its high fatality rates, sporadic outbreaks, and limited treatment options. As global health systems face increasing pressures from climate change, urbanization, and land-use changes, sustainable and integrated approaches to disease monitoring and outbreak preparedness are essential. This chapter explores the strategic application of sustainability principles in the surveillance and managing Nipah virus, highlighting the importance of early detection systems, low-cost diagnostic tools, and equitable public health infrastructure. A central theme of the chapter is adopting the One Health approach, which acknowledges the interconnectedness of human, animal, and environmental health. By examining ecological drivers such as habitat encroachment, deforestation, and agricultural intensification, the chapter emphasizes how anthropogenic changes contribute to zoonotic spillover risks. It also addresses the role of community engagement, cross-sector collaboration, and policy innovation in building resilient health systems responsive to NiV and similar threats. The discussion further outlines how effective NiV control supports multiple Sustainable Development Goals (SDGs), particularly those related to health, environmental protection, and global partnerships. The chapter offers a framework for long-term, sustainable outbreak prevention and control by integrating science-based strategies with ethical and governance considerations. The findings provide critical insights for policymakers, researchers, and practitioners looking to enhance preparedness and reduce vulnerability to future zoonotic epidemics.