Marburg Virus Disease remains one of the world’s most lethal viral hemorrhagic fevers, with a high case fatality rate, severe socioeconomic consequences, and escalating risks due to ecological disruptions and globalization. This chapter explores how sustainable innovations can transform Marburg virus surveillance, diagnosis, and public health response. It begins by examining the virus’s epidemiology, zoonotic spillover from its natural reservoir (Rousettus bats), and complex transmission pathways amplified by healthcare exposure, unsafe burial practices, and cross-border mobility. Public health responses remain limited by weak healthcare infrastructure, delayed diagnostics, insufficient community engagement, and fragmented global preparedness. Sustainable diagnostic innovations such as low-cost point-of-care molecular tests, mobile laboratories, and AI-powered surveillance systems are essential to facilitate early detection, rapid containment, and equitable access to care in resource-constrained regions. This chapter also emphasizes strengthening health systems through workforce capacity building, resilient infrastructure, infection prevention and control, and community-driven participatory approaches. Culturally sensitive risk communication strategies are discussed as a critical pillar in reducing stigma, countering misinformation, and fostering community trust. Furthermore, the chapter highlights policy frameworks for multisectoral collaboration, long-term financing, and global cooperation aligned with the Sustainable Development Goals. As zoonotic threats emerge, an integrated One Health approach connecting human, animal, and environmental health offers the most promising pathway toward resilient, sustainable management of Marburg virus outbreaks and broader pandemic preparedness.