This book chapter explores how cloud-based blockchain technology for vaccine supply chain applications can be technically sustainable in the Greater Bay Area. To explore the technical sustainability, the user’s intention to adopt the cloud-based blockchain for vaccine supply chain applications has to be proposed, especially at this infancy stage of implementing the supply chain applications using such a new blockchain technology. For this exploration of technical sustainability, the integration of the models of Task-Technology Fit and Unified Theory of Acceptance and Use of Technology is used. The significance of the book chapter is twofold. First, there is a trend of adopting this new blockchain technology in supply chains around the world for the main reason that the blockchain features present promising opportunities for improvement across the supply chain operations around the world. This proposed study investigates this important issue of sustainable development of blockchain technology for vaccine supply chain applications in the Greater Bay Area in order to understand the feasibility of adopting blockchain technology in supply chains in the Greater Bay Area to cope with the trend in the world. For this investigation, a new and more appropriate model by integrating Task-Technology Fit and the Unified Theory of Acceptance and Use of Technology is adopted. Second, while previous studies suggested and reported sustainable practices of applying blockchain technology in supply chains in many countries around the world, how these practices apply to the Greater Bay Area has not been thoroughly explored in the literature. This proposed study targets to fill this gap by exploring technical sustainable practices.