Iatrogenic allogenosis (IA) is an incurable disease, where the ideal treatment, extraction of modeling substances, is complex and risky. In this context, this chapter explores the use of regenerative therapy based on nanofat lipotransfer as an alternative to treat skin alterations secondary to this condition, aiming to improve patients’ quality of life. Following an exhaustive literature review that revealed scarce information on the subject, this technique was applied in 63 patients, achieving positive results in all cases, with notable improvement in skin texture, coloration, and structure, and without any reported complications. The mechanisms of action of adipose-derived stem cells explain the observed reduction in hyperpigmentation and dermal regeneration. The experience presented suggests that regenerative therapy with nanofat is a safe, minimally invasive, and effective option, opening new perspectives for the management of a disease that is otherwise difficult to treat.