As physicians, we find ourselves increasingly being called to deal with problems generated by injection-induced breast siliconomas: bilateral breast tumors, some painful, challenging masses that are often confused with advanced breast cancer, axillary tumors, etc. To this is added the extreme difficulty of ruling out breast cancer through physical examinations, mammography, ultrasound, and even magnetic resonance imaging (MRI). Our experience, over almost 25 years treating and investigating this pathology, has shown us that a multidisciplinary therapeutic team is required to treat these patients with such complex diseases. Moreover, that team must have a comprehensive vision and be committed to tailoring treatment to each patient individually. The team also must act in a coordinated manner, addressing all the different implications of disease, whether local or systemic, physical, or psychological. The injection of silicones and other oils has had an unfavorable social impact because it incapacitates many people during the most productive years of their lives. We will now present the appropriate therapeutic approaches for each mammary siliconoma.