Opioid use disorder (OUD) is a chronic condition stemming from the misuse of prescription opioids or illicit opioid substances like heroin, representing a significant public health challenge that contributes to over 120,000 opioid-related deaths annually. Often, OUD begins with prescribed opioids for pain management, but related to tolerance, clinicians ceasing to prescribe opioid medication, and dependence issues, individuals may transition to illicit drug use. Effective treatment involves a combination of medications, such as methadone, buprenorphine, and naltrexone, along with behavioral therapies. Integrating OUD treatment into chronic pain management is crucial, as long-term opioid therapy for pain can increase the risk of misuse. Early detection using validated screening tools, e.g., the Current Opioid Misuse Measure (COMM) and the Opioid Risk Tool (ORT), plays a key role in improving outcomes. Addressing the stigma associated with OUD is essential to ensure that patients seek treatment without fear of judgment. Barriers to care include limited access to specialized providers, insurance restrictions, and the ongoing stigma surrounding opioid use. Collaborative care models, where addiction specialists, pain management teams, and primary care physicians and providers work together, are vital for providing comprehensive and patient-centered treatment. By promoting early screening, improving access to evidence-based treatments, and reducing stigma, clinicians can mitigate the impact of OUD and improve overall patient outcomes and public health.