The barrier methods of contraception include male and female condoms as well as diapraghm, cervical cap, spermicides, and vaginal sponge. Male condoms are the most commonly used methods. Several studies have shown that male condom protects against HIV infection, in particular, in heterosexual relationship. Considering MSM relationship, always-use is 60–70% effective. There is also good epidemiological evidence that condoms reduced the risk of gonorrhea and chlamydia. Laboratory studies indicate that the female condom is an effective mechanical barrier to viruses, including HIV. However, few clinical data are available on the efficacy of female condoms in providing protection from STDs, including HIV. Recent evidence has indicated that vaginal spermicides containing nonoxynol-9 (N-9) are not effective in preventing cervical gonorrhea, chlamydia, or HIV infection In conclusion, male latex condom is the only barrier method that has been shown in human studies to prevent the transmission of all types of STDs, including HIV. The protection is mainly observed in users. The female condom may prove to be as effective as the male condom, but studies are lacking.