Through automation, AI-driven process control, intelligent manufacturing, quantum computing, and sustainability, Industry 6.0 is transforming the chemical industry. This chapter examines how digital twin simulations, real time process monitoring, and predictive analytics are integrated in AI-powered smart factories to enhance chemical synthesis, refinement, and polymer manufacture. Autonomous reactors, IoT-enabled sensors, and AI-driven quality control systems are improving on traditional batch and continuous synthesis techniques, increasing output while consuming less energy and producing less waste. Decarbonization in chemical manufacturing is being propelled by developments in sustainable chemistry, including electrochemical CO₂ reduction, green solvent-free processes, and AI-assisted carbon capture. Blockchain-enabled supply chain transparency is another feature of Industry 6.0 that lowers fraud and enhances adherence to international laws like REACH and GHS. AI and nano catalysts, increase the efficiency of chemical synthesis, reducing reaction time and energy consumption. Enzymatic textile waste processing and advanced chemical recycling help achieve the circular economy’s objectives by cutting down on landfill waste. By combining automated logistics, robotics, and zero-liquid discharge systems, operational efficiency is further increased while environmental effect is reduced. According to economic study, Industry 6.0 transitions provide long-term cost reductions and a quick return on investment of 1.5–2 years. This change guarantees that the chemical sector supports intelligent, sustainable, and future ready manufacturing in line with SDGs 9, 12, and 13.