The Mediterranean Basin faces escalating threats from earthquakes and coastal subsidence, as exemplified by Libya’s rising seismic activity and projections that 20% of Alexandria and Egypt could submerge by 2050. This study employs a secondary research methodology to analyse how interior architecture using locally sourced, multi-hazard-resistant materials can mitigate displacement and preserve cultural heritage. By synthesising geospatial data, material science studies, and policy reports, this study proposes adaptive solutions, such as fibre-reinforced polymers, self-healing lime plaster, and flood-resistant recycled composites. The findings advocate a paradigm shift in disaster resilience from structural overhauls to interior material innovation, offering a scalable framework for at-risk Mediterranean cities.