The existing European building stock is responsible for a relevant impact in terms of greenhouse gas (GHG) emissions and total energy consumption. Effective renovation strategies need to be defined and tested to meet the European Union 2050 decarbonisation target. In this context, urban mapping supported by a GIS-based procedure allows for the identification of eligible areas to evaluate the applicability of deep renovation solutions. This research studies the applicability of the innovative technologies e-PANEL, e-CLT, and e-EXOS, defined within the framework of the European H2020 project “e-SAFE – Energy and Seismic AFfordable rEnovation solutions”. They are characterized by assembly with dry construction techniques according to the principles of circularity and low environmental impact, as well as reduced disturbance for the inhabitants. Their combination enables energy retrofit (e-PANEL) and seismic resistance enhancement (e-CLT and e-EXOS) of existing buildings. The presented methodology supports the identification of a sample of suitable urban blocks in the Municipality of Athens, part of the Athens Metropolitan Area (AMA), one of the most vulnerable areas to seismic risk and climate change. The main outcome is the identification of implementation rates for each e-SAFE system as a preliminary indicator/decision support tool to measure the impact and guide targeted long-term strategies for building retrofitting.