With the increasing demand for sustainable and efficient building materials, there is a pressing need to explore innovative solutions that combine advanced manufacturing techniques with environmentally friendly materials. This study aims to identify the key parameters influencing the performance of 3D-printable clay bricks. To this purpose, Voronoi parametric models are used for a multiperformance analysis, – including thermal, structural, and acoustic assessments – supported by detailed statistical evaluation. The research demonstrates the versatility of Voronoi diagrams in creating complex geometries and identifying critical parameters such as wall thickness and cell distribution that affect performance. The thermal analysis highlights the importance of minimizing thermal path length (TPL) to reduce thermal transmittance. In structural evaluations, geometric regularity is shown to enhance stability. Acoustic assessments indicate that increasing wall thickness and cell density improves sound insulation (Rw). Finally, the study also emphasizes the potential sustainability of clay as a building material, noting its lower environmental impact compared to cement and its compatibility with 3D printing technology. The findings provide a framework for optimizing design processes and lay the groundwork for future research focused on performance-driven, sustainable construction methods.