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Drug resistance hinders cancer treatment and directly affects cancer outcome and survival rate. While drug resistance is one of the worst features of cancers, there is limited knowledge about its mechanism and initiation in cancers. Noncoding RNAs are one of the most impactful epigenetic elements that are deregulated in many diseases. There is a strong correlation between cancers and noncoding RNAs. In this regard, we tried to find the connection between cancers and this epigenetic factor. In our investigation, we find an axis in which circular RNA, a dominant type of noncoding RNA, could regulate miRNA to control mRNA degradation. We encountered many deregulated pathways and tried to explain the mechanism underlying the CirRNA/miRNA/mRNA axis in drug resistance of cancer, including the most widely recognized resistance type of cancer in the body.

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The Transcriptional Role of Circular RNAs in Drug Resistance by Modulating the miRNA/mRNA Axis

  • 章节

  • 发表日期：

    2026年

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  • Mohammad H. Ghazimoradi,
  • Amirmohammad Moghadam,
  • Parastoo Akbarabadi,
  • Sadegh Babashah

摘要

Drug resistance hinders cancer treatment and directly affects cancer outcome and survival rate. While drug resistance is one of the worst features of cancers, there is limited knowledge about its mechanism and initiation in cancers. Noncoding RNAs are one of the most impactful epigenetic elements that are deregulated in many diseases. There is a strong correlation between cancers and noncoding RNAs. In this regard, we tried to find the connection between cancers and this epigenetic factor. In our investigation, we find an axis in which circular RNA, a dominant type of noncoding RNA, could regulate miRNA to control mRNA degradation. We encountered many deregulated pathways and tried to explain the mechanism underlying the CirRNA/miRNA/mRNA axis in drug resistance of cancer, including the most widely recognized resistance type of cancer in the body.