The intervention phases of trauma-informed, culturally based intervention (TICBI) focus on the positive transformation needed to promote resilience and well-being. The phase starts with evaluating the survivor’s adaptation, including their behaviors, cultural nuances, and the impact of past traumas and triggers on their day-to-day life. The intervention process involves the social worker and their clients focusing on strategies for change and developing sustainable behaviors that foster healing and growth. Each identified intervention approach in this chapter is based on the premise that the human brain and body are inherently adaptive, prioritizing survival needs over other necessities such as socialization and connection (parasympathetic activation). The intervention phase provides survivors with the opportunity, during talk therapy, to discuss, reflect, and practice healing methods designed to enhance their self-awareness and motivation for making the needed change. It is a chance that builds on established relationships, respectful cultural communication, and collaboration. Using case studies relevant to each mindset will explore the change process. The first case study represents a survivor stuck in an active sympathetic response (fight, flight, or freeze). The other two case studies represent survivors who, prior to their triggering incident or recent crisis, exhibited parasympathetic responses (therapeutic and active, engaged mindset) and are now dealing with a return to their past survival responses and sympathetic activation.