The COVID-19 pandemic heightened public awareness of health risks associated with indoor environments, where individuals typically spend around 80–90% of their time. The World Health Organization (WHO) has identified ventilation in healthcare settings as a critical area for reducing infection risks and enhancing thermal comfort in hospitals. Research indicates that human behaviors, such as posture, movement, and speech, can influence the effectiveness of ventilation systems in controlling indoor contamination. However, current studies predominantly focus on technological controls and often overlook monitoring occupant bio signals within micro-environments. This paper reviews user-centric approaches to improving ventilation performance in hospital wards, exploring novel strategies tailored to personalized needs, which considers occupant-targeted ventilation, local air cleaning methods, wearable de-vices, and IoT technologies. The differences and application conditions of these approaches are elaborated in the review paper, highlighting advancements that address both functional performance and user comfort. The paper provides in-sights into the potential of integrated demand-based ventilation systems for optimizing healthcare indoor climate. The findings of this review will set a foundation for future experimental designs in future hospital settings.